AB0575 MESANGIAL C1Q DEPOSITION, BUT NOT C3 AND C1Q DEPOSITION IN OTHER RENAL COMPARTMENTS, IS A PREDICTOR OF RENAL OUTCOME IN LUPUS NEPHRITIS

Background Complement activation is an important pathophysiological process in the pathogenesis and development of systemic lupus erythematosus nephritis (LN). However, prognostic value complement factors deposition different kidney compartments has received little attention and, to best our knowledge, no study examined its association with renal outcomes LN. Objectives To evaluate significance C1q C3 tissue compartments. Methods We have conducted a retrospective cohort collected data on demographics, clinical laboratory parameters histopathology (light, immunofluorescent electron microsopy) at time biopsy after long-term follow-up. expression graded (mesangium, glomerular basement membrane (GBM), tubular (TBM) blood vessel wall) dichotomized into or low (grades 0 1) high 2 3). Remission (defined as complete partial remission) was defined per EULAR 2019 guidelines. Results A total 51 patients biopsy-proven LN were followed up for 4.5±2.9 years (80% women, mean age 38±14). 29 (71%) achieved remission. follows: mesangium (C1q 54%, 59%), GBM 34%, 41%), TBM 5%, 5%) wall 0%, 5%). Patients proliferative had more frequently (69% vs. 14%, p<0.001 72% 29%, p=0.005, respectively), while there differences between non-proliferative other (all p>0.05). Subjects who remission (64% 31%, p=0.045), but Interestingly, mesangial outcome significant even adjustment biopsy, gender type (proliferative non-proliferative) (OR 0.13 [0.02, 0.98], p=0.047). Conclusion might be factor aggressive treatment these may explain better patients. Disclosure Interests None declared